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C.I. Acid Blue 90, monosodium salt (8CI)

Brilliant Blue G

CAS: 6104-58-1

Molecular Formula: C47H48N3NaO7S2

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C.I. Acid Blue 90, monosodium salt (8CI) - Names and Identifiers

Name Brilliant Blue G
Synonyms C.I. 42655
Acid Blue 90
Brillant blue G
Brilliant Blue G
C.I. Acid Blue 90
Coomassie Blue G250
Brilliant Blue G250
Acid Blue 90 (42655)
C.I. Acid Blue 90 (VAN)
brilliant blue G concentrate
brilliant blue G-tca solution
brilliant blue G (C.I. 42655)
C.I. Acid Blue 90, monosodium salt (8CI)
brilliant blue G-perchloric acid*solution
N-[(1E)-4-({4-[(4-ethoxyphenyl)amino]phenyl}{4-[ethyl(3-sulfobenzyl)amino]-2-methylphenyl}methylidene)-3-methylcyclohexa-2,5-dien-1-ylidene]-N-(3-sulfobenzyl)ethanaminium
CAS 6104-58-1
EINECS 228-058-4
InChI InChI=1/C47H49N3O7S2/c1-6-49(31-35-11-9-13-43(29-35)58(51,52)53)40-21-25-45(33(4)27-40)47(37-15-17-38(18-16-37)48-39-19-23-42(24-20-39)57-8-3)46-26-22-41(28-34(46)5)50(7-2)32-36-12-10-14-44(30-36)59(54,55)56/h9-30H,6-8,31-32H2,1-5H3,(H2,51,52,53,54,55,56)/p+1
InChIKey JFNOCRSXNFZMNT-UHFFFAOYSA-M

C.I. Acid Blue 90, monosodium salt (8CI) - Physico-chemical Properties

Molecular FormulaC47H48N3NaO7S2
Molar Mass854.02
Melting Point100 °C
Flash Point11 °C
Water SolubilitySoluble in water (50 mg/ml) and ethanol (40 mg/ml).
Solubility Soluble in ethanol and hot water is bright blue, slightly soluble in cold water.
AppearanceForm Solid, color Dark blue-violet-brown
Storage Condition2-8°C
MDLMFCD00078482
Physical and Chemical PropertiesChemical properties dark brown powder. Slightly soluble in cold water, dissolved in hot water, the aqueous solution is bright blue, adding sodium hydroxide solution to turn purple. It is bright blue when dissolved in ethanol. It is blood red in concentrated sulfuric acid and orange red after dilution.
UseUses acid brilliant blue G is a disperse dye, used for wool, silk, nylon dyeing, bright color, good wet treatment fastness, poor light fastness, wool fabric less application. Also used for wool, silk, nylon fabric direct printing, as well as leather, paper coloring. In biochemical studies, for gel electrophoresis protein staining. Does not penetrate into the glue than Naphthol Blue Black B1(Naphthol Blue Black B1) 3 times higher sensitivity, simple and sensitive; Can be carried out a variety of protein detection, chemicals and free amino acids implicated in the Lowry reaction had no effect on this protein staining. Acid blue 90 is also a P2X7 purinergic receptor agonist.

C.I. Acid Blue 90, monosodium salt (8CI) - Risk and Safety

Safety DescriptionS24/25 - Avoid contact with skin and eyes.
WGK Germany3
TSCAYes
HS Code32041200

C.I. Acid Blue 90, monosodium salt (8CI) - Upstream Downstream Industry

Raw MaterialsBenzaldehyde
Phenetidine
Ethylbenzyltoluidine
Phenetidine
Ethylbenzyltoluidine
Benzaldehyde
Downstream ProductsErioglaucine disodium salt
ACID BLUE 9 ALUMINUM LAKE

C.I. Acid Blue 90, monosodium salt (8CI) - Reference

Reference
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C.I. Acid Blue 90, monosodium salt (8CI) - Nature

solubility H2O: soluble1mg/mL
color index 42655
BRN 5230822
EPA chemical information C. I. Acid Blue 90 (6104-58-1)
Last Update：2024-04-10 22:29:15

C.I. Acid Blue 90, monosodium salt (8CI) - Uses and synthesis methods

biological activity

Brilliant Blue G (BBG) is an effective P2X7 receptor competitive antagonist. The IC50 values for rat P2X7 and human P2X7 are 10.1 nM and 265 nM, respectively. Brilliant Blue G (BBG) is a dye commonly used to dye or quantify proteins in laboratories.

target

Target Value

rat P2X7

(Cell-free assay) 10.1 nM

human P2X7

(Cell-free assay) 265 nM

production method

Using benzaldehyde, N-benzyl-N-ethyl m-toluidine (N-benzyl-N-ethyl-m-toluidine), and p-aminophenyl ether as raw materials, benzaldehyde is first condensed with N-benzyl-N-ethyl m-toluidine, and then The condensation product is sulfonated to obtain a trisulfonic acid compound, which is then oxidized and reacted with p-aminophenyl ether to obtain the product after neutralization. The finished product is salted out, filtered, dried and crushed.

1000kg N-ethyl-N-benzyl m-toluidine is added to a mixed solution composed of 214kg 100% sulfuric acid, 126kg of ice and 14kg of ethanol, then 245kg of benzaldehyde is added, reacted at 100 ℃ for 50h, heated to 110 ℃ within 10h to evaporate part of the water, then the material is quickly poured into the plate, a large amount of water is evaporated, and about 1500kg of condensate is obtained.

750kg of condensate was added to 1500kg 100% sulfuric acid within 24 hours until it was completely dissolved. 1040kg 65% fuming sulfuric acid was added dropwise below 30 ℃ and stirred until the reaction was complete. Then pour into 3000L of water and 1500kg of ice, heat to 80 ℃, add 2700kg of sodium sulfate, precipitate sulfonated products, and filter.

dilute 1/4 of the sulfonated product with water, add 20kg 50% acetic acid and 30kg 30% hydrochloric acid, heat to 45 ℃, then add 96kg 100% lead peroxide (mixed into paste with 200L of water), react for 30min, add 80kg of sodium sulfate, precipitate lead salt, and filter at 45 ℃. The filtrate is salted out with 20% salt solution (by volume), filtered, the filter cake is washed with 20% salt water, and vacuum dried at 95 ℃ to obtain oxidized products.

600kg of oxidation product is taken, added to 750kg of p-ethoxyaniline at room temperature, heated to 100-105 ℃, reacted for 3.5h, cooled to 60-70 ℃, 5000L of water and 800kg 30% hydrochloric acid mixed solution are added, stirred for 1h, siphoned to remove p-ethoxyaniline mother liquor, then 2000L of hot water is added, stirred for 30min, and after standing still. The viscous dye is dissolved in 35kg of sodium chloride and 30kg of sodium acetate in hot water, and then about 80kg of acetic acid is added to acid, the dye is precipitated, the waste water is siphoned off, and the dye is dried in vacuum to obtain about 500kg of dye.

Last Update：2024-04-10 22:29:15
C.I. Acid Blue 90, monosodium salt (8CI)
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Mobile: +86-18621343501
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View History
C.I. Acid Blue 90, monosodium salt (8CI)
RARECHEM AL BD 0010
(4-Bromophenylethynyl)trimethylsilane
3-(4-硝基苯基)丙炔酸
3-[N-ETHYL-4-(4-NITROPHENYLAZO)PHENYLAMINO]PROPIONITRILE
5-羧基-4-甲基噻唑
Cyclopropanecarboxamide,N-(1-methylethyl)-2-(phenoxymethyl)-, trans- (9CI)
SUGAMMADEX SODIUM舒更葡糖钠
2-溴丁-2-烯二酸
叔丁氧羰基-天冬氨酸α苄脂
Raw Materials for C.I. Acid Blue 90, monosodium salt (8CI)
Benzaldehyde
Phenetidine
Ethylbenzyltoluidine
Phenetidine
Ethylbenzyltoluidine
Benzaldehyde
Downstream Products for C.I. Acid Blue 90, monosodium salt (8CI)
Erioglaucine disodium salt
ACID BLUE 9 ALUMINUM LAKE
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